Tardive dystonia due to aripiprazole use in a neuroleptic-naive patient.

To the Editor: Lungu et al1 published the first 2 cases of tardive dyskinesia due to aripiprazole in neuroleptic-naive subjects. Both of these subjects had tardive dystonia. One, a 19-year-old woman, had fragile X syndrome and developed her problem after 3 months of aripiprazole treatment. The other, a 56-year-old man, had no preexisting neurologic disorder and developed his movements after 18 months of aripiprazole treatment. Although other tardive syndromes have been ascribed to aripiprazole,2–4 all of the individuals had prior exposure to dopamine receptor–blocking drugs. The following is an additional case of tardive dystonia due to aripiprazole in a neuroleptic-naive woman with no history of neurologic problems.